I've had quite a few hand issues in recent years and had to drop to a 9-42 set so I don't get fatigue if I've not played for ages. Though my SL has 10's on it and they feel ok given the scale length.
Fender Classic Player 60’s Stratocaster>East Coast T1 Tele>
Epiphone Les Paul SL>Ovation 12 String acoustic>Peavey Strat DIY Relic
Marshall Origin 20H>James’s old purple 2x10
Marshall MG10 Combo
I popped a set of the mammoth slinkys on my tele. Nice heavy low strings for drop tunings. Not convinced about the wound g though.
The low 'E' and 'A' strings do sort of sit on rather than in the nut a bit. But I don't really care about that.