Often times when running a two-amp setup, you'll get problems where the amps or speakers are out of phase or the room is doing odd things; all causing phase cancellation, making your shit sound weedy and swooshy. Not cool, especially if you don't want to sound weedy and swooshy.
To illustrate my awesome solution to this in a live situation (which I'll be using from now on in Casa Bonita), I ran my pedalboard into 2 channels on my mixer, panned hard left and right.
The delay between the two amps avoids these phase issues, with the added bonus of a slight thickening effect, much like the "Double Tracking" delay on the Polychorus, pour examplé.
In a live situation, you don't have the ability to hard pan each amp into the audience's earholes, making the phase issue even more of a problem in a real life live situation. THIS'LL SORT Y'ALL OUT!